Breast adenomyoepithelioma from a radiologic perspective.

Adenomyoepithelioma of the breast (AB) is an uncommon tumor that is characterized by the biphasic proliferation of epithelial and myoepithelial cells. The radiologic findings for AB have been scantly reported. This paper aims to analyze the characteristic findings for AB on ultrasonography (US) and mammography. This retrospective descriptive study used the Breast Imaging-Reporting and Data System (BI-RADS) to analyze the US and mammography findings for histologically confirmed AB in patients attended at our institution between 2007 and 2019. We identified a total of 13 AB in 13 women. All patients underwent US. On US, 12 lesions were seen as oval nodules, and the remaining lesion was irregular-shaped; 8 lesions had circumscribed margins, 3 had angled margins, and 2 had microlobulated margins. Regarding the echo pattern, 8 lesions were hypoechoic and 5 were complex (solid-cystic). On color Doppler, 11 lesions were vascularized nodules and 2 were avascular nodules. In conclusion, we present the imaging characteristics for a series of cases of AB. It is unlikely that this lesion can be suspected solely on the basis of the imaging findings; nevertheless, it is important for radiologists to be familiar with AB to carry out a good radiopathologic correlation.

Breast adenomyoepithelioma from a radiologic perspective. / Adenomioepitelioma de la mama desde una perspectiva radiológica.

Adenomyoepithelioma of the breast (AB) is an uncommon tumor that is characterized by the biphasic proliferation of epithelial and myoepithelial cells. The radiologic findings for AB have been scantly reported. This paper aims to analyze the characteristic findings for AB on ultrasonography (US) and mammography. This retrospective descriptive study used the Breast Imaging-Reporting and Data System (BI-RADS) to analyze the US and mammography findings for histologically confirmed AB in patients attended at our institution between 2007 and 2019. We identified a total of 13 AB in 13 women. All patients underwent US. On US, 12 lesions were seen as oval nodules, and the remaining lesion was irregular-shaped; 8 lesions had circumscribed margins, 3 had angled margins, and 2 had microlobulated margins. Regarding the echo pattern, 8 lesions were hypoechoic and 5 were complex (solid-cystic). On color Doppler, 11 lesions were vascularized nodules and 2 were avascular nodules. In conclusion, we present the imaging characteristics for a series of cases of AB. It is unlikely that this lesion can be suspected solely on the basis of the imaging findings; nevertheless, it is important for radiologists to be familiar with AB to carry out a good radiopathologic correlation.

Efecto hipotensor agudo del ejercicio de oclusión vascular sobre adultos mayores / Acute hypotensor effect of the vascular occlusion exercise on elderly adults

Objetivo: El objetivo de este estudio fue evaluar la respuesta cardíaca aguda después de realizar una sesión de ejercicio con oclusión vascular en adultos mayores (AM). Sujetos y método: 22 participantes voluntarios, fueron sometidos al protocolo experimental de ejercicio dinámico de prensión manual con un 30% de presión de oclusión (PO), después de registrar los valores basales y en reposo de presión arterial sistólica (PAS), presión arterial diastólica (PAD) y frecuencia cardíaca (FC). Evaluadas en condiciones basales y entre los 5 y 30 minutos post-oclusión. Resultados: Al finalizar el protocolo se observó una reducción significativa en la PAS y FC a los 15', 20' y 25' (p<0,05) y para la PAD a los 10' y 20' (p<0,05). Conclusión: El efecto agudo del ejercicio con oclusión vascular genera una reducción significativa de PAS, PAD y FC hasta 25 minutos post-oclusión, en los AM analizados

The objective of this study was to evaluate the acute cardiac response after performing an exercise session with vascular occlusion in elderly adults (EA). Twenty-two volunteer participants underwent the experimental protocol of dynamic manual grip exercise with 30% occlusion pressure (OP), after recording the baseline values and resting systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR). All measures were taken in basal conditions and between 5 and 30 minutes' post-occlusion. At the end of the protocol, there was a significant reduction in SBP and HR at 15 ', 20' and 25 '(p <0.05) and for DBP at 10' and 20 '(p <0.05).). The acute effect of exercise with vascular occlusion generates a significant reduction of SBP, Basal Diastolic Pressure (BDP) and HR up to 25 minutes' post-occlusion, in the EA analyzed

Determinación del índice facial total y cono facial en individuos chilenos / Total facial index and facial cone in Chilean individuals

El estudio fue realizado en 68 estudiantes, adultos, Chilenos, de ambos sexos, con edades entre 17 y 32 años, oriundos de la Región de la Araucanía, Chile. En cada uno se registraron el diámetro vertical (Nasion-Gnation, Na-Gn) y diámetros transversales (bigoníaco y bicigomático, Go-Go y Cig-Cig, respectivamente) y se calculó el índice facial total (IFT). Para la obtención del cono facial se compararon los anchos Go-Go y Cig-Cig. Se analizó la relación entre: IFT v/s cono facial; IFT v/s sexo; cono facial v/s sexo. Para el análisis estadístico se utilizó las pruebas de chi-cuadrado, Pearson y coeficiente de correlación de Spearman, considerándose significativo p<0,05. La altura de la cara (Na-Gn) fue de 117,5 mm en hombres y de 110,3 mm en mujeres; el ancho superior de la cara (Cig-Cig) fue de 126,9 mm en los hombres y de 124,4 mm en las mujeres. La altura facial es diferente para hombres y mujeres, siendo mayor en hombres. El IFT fue calculado a partir de las medidas registradas y se obtuvo lo siguiente: en hombres hubo 4 casos (5,9 %) euriprosopos, 4 (5,9 %) mesoprosopos y 17 (25 %) leptoprosopos; en mujeres hubo 12 casos (17,6 %) euriprosopos, 12 (17,6 %) mesoprosopos y 19 (27,9 %) leptoprosopos. Concluimos que en individuos adultos chilenos la altura facial es diferente para hombres y mujeres, siendo mayor en hombres. El tipo leptoprosopo y la cara de forma triangular son más frecuentes en hombres. Los datos obtenidos son un aporte al conocimiento antropológico de un grupo de individuos del Sur de Chile.

The study was conducted on 68 students, Chilean adults, of both sexes, between 17 and 32 years old, originally from the Region de la Araucanía, Chile. The vertical diameter (Nasion-Gnation, Na-Gn) and transverse diameter (bigoníac and bizygomatic; Go-Go and Zig-Zig, respectively) were recorded and total facial index (TFI) was calculated. To obtain the facial cone widths Go-Go and Zig-Zig were compared. We analyzed the relationship between: TFI v/s facial cone; TFI v/s sex; facial cone v/s sex. For statistical analysis the chi-square test, Pearson and Spearman correlation coefficient was used, considering significant p <0.05. The face height (Na-Gn) was 117.5 mm in men and 110.3 mm in women; the width of the upper face (Zg-Zg) was 126.9 mm in men and 124.4 mm in women. The facial height is different for men and women, being higher in men. The TFI was calculated from the measurements recorded and the following is obtained: in men there were 4 cases (5.9 %) euriprosopic, 4 (5.9 % ) mesoprosopic and 17 (25 %) leptoprosopic; in women there were 12 cases (17.6 %) euriprosopic, 12 (17.6 %) mesoprosopic and 19 (27.9%) leptoprosopic. We hereby conclude that in Chilean adults the facial height is different for men and women, being higher in men. The leptoprosopic type and triangular face is more common for men. The data obtained is a contribution to anthropological knowledge of a group of individuals in the South of Chile.

Does serum rheumatoid factor have an influence on the clinical picture of ankylosing spondylitis?

OBJECTIVE: To describe the influence of serum rheumatoid factor (RF) on the clinical and radiological picture of definite ankylosing spondylitis (AS). METHODS: In a retrospective chart review of 281 AS patients typed for RF, the clinical picture of RF positive patients (Group 1) was compared with RF negative patients (Group 2); mode of onset, disease duration, and treatment were recorded. All patients were examined to determine their clinical status; the blood cell count. HLA-B27, serum IgG, IgM, IgA, and erythrocyte sedimentation rate (ESR) were determined, and radiological studies of the entire spine, pelvis and affected peripheral joints were carried out. In patients from Group 1 the HLA-DR was also determined. RESULTS: Fifteen of 281 patients (8 men, 7 women) with AS were RF+ (1:64 to 1:1024) (5.3%) and 11 were HLA-B27+. Seven patients in Group 1 had spine involvement and chronic arthritis of the knees. Four out of these 7 were tested for DR, and none was positive; in 6, AS and rheumatoid arthritis (RA) coexisted, 2 were DR1 and 2 were DR4 (test not carried out in 2). In two others we found spinal involvement only, and one of them had both DR1 and DR4. The onset of AS was similar in both groups. Group 1 was characterized by a chronic disease of moderate intensity with chronic arthritis of the metacarpophalangeal and proximal interphalangeal joints (p = 0.0008 and p = 0.04, respectively), no valvulopathy (p = 0.04) and fewer uveitis sequelae (p = 0.007) than Group 2. The ESR (p = 0.01), IgG (p = 0.008) and IgM (p = 0.0001) were higher in Group 1 than in Group 2. CONCLUSIONS: The presence of RF in AS is associated with a chronic disease of moderate intensity with chronic peripheral arthritis and fewer extra-articular manifestations. The presence of RF, not always associated with HLA-DR, seems to affect the course of AS and does not necessarily indicate an association with RA.

Measurement of clinical activity of systemic lupus erythematosus and laboratory abnormalities: a 12-month prospective study.

OBJECTIVE: To assess flares in outpatients with systemic lupus erythematosus (SLE) using SLAM (systemic lupus activity measure) and to determine laboratory abnormalities as predictors of disease activity. METHODS: Fifty-three Mexican patients were assessed using SLAM scale. They were evaluated monthly for a total of at least 572 months. The SLAM scale was applied at each visit. Samples were drawn for complete blood cell count, erythrocyte sedimentation rate, urinalysis, 24-h protein and creatinine clearance, anti-DNA, C3 and C4. An SLE flare was defined as the occurrence of new clinical manifestations or worsening compared to the previous month that usually required restarting or increasing prednisone or immunosuppressive drugs. RESULTS: Thirty-three patients had flares, mainly in minor organs. The incidence of flares was 0.69/patient/year of followup. Active nephritis and extrarenal manifestations correlated with high levels of dsDNA and low complement levels. We found an odds ratio (OR) = 3 (CI = 1.7-5.7) for flare in asymptomatic patients with high dsDNA and OR = 2 (CI = 1.3-4.5) for low C3 levels. CONCLUSION: Flares are frequent in patients with SLE and they occur independent of disease duration and the time the disease has been under control. Flares are apparently predictable and are related to serologic abnormalities.

Testicular function in active ankylosing spondylitis. Therapeutic response to human chorionic gonadotrophin.

Testicular function was studied in 22 patients with ankylosing spondylitis (AS) with serum measurements of hormone levels, seminal fluid analysis and testicular reserve test. Results were correlated with disease activity. The abnormal findings were elevated luteinizing hormone (LH), inversion of estradiol/testosterone ratio (E2:T) and diminished testicular reserve for testosterone (T) and slightly increased for estradiol (E2). Nine patients with severe active AS received biweekly 2,500 IU of human chorionic gonadotrophin injections with a resulting increase in E2 serum levels. When the values of E2 reached 40 pg/ml or higher, there was a decrease of the sedimentation rate (p less than 0.05) and a reversal to normal of the E2:T ratio. This was accompanied by an improvement in AS at the 10th week that lasted up to 9 weeks after discontinuation of treatment. Our findings suggest a possible role of sex hormones in the physiopathogenesis of AS and offers a possible therapeutic alternative.

[Functional abnormalities of complement in familial and sporadic ankylosing spondylitis]. / Anormalidades funcionales del complemento en la espondilitis anquilosante familiar y esporádica.

Levels of complement fractions of 12 patients with sporadic ankylosing Spondylitis and 6 patients with familial Ankylosing Spondylitis (N. Y. Criteria) were studied by an hemolytic and functional method (microhemolysis in plate. Cordis Lab. Miami, Fla. USA). Abnormal levels were found in 94% of them high levels of C1 and C2 (p 0.002), and C3 (p 0.05) C8 and C9 (p 0.001) deficiencies, mixed or isolated, correlated with the severity of the diseases. C9 deficiency belongs to familial Ankylosing Spondylitis. These functional deficiencies of serum complement can favor the colonization and persistence of germs, which could mediate in the genesis of Ankylosing Spondylitis.